On the use of DNA pooling to estimate haplotype frequencies.

Abstract excerpt

Genome-wide association studies may be necessary to identify genes underlying certain complex diseases. Because such studies can be extremely expensive, DNA pooling has been introduced, as it may greatly reduce the genotyping burden. Parallel to DNA pooling developments, the importance of haplotypes in genetic studies has been amply demonstrated in the literature. However, DNA pooling of a large number of samples...

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• Genetics, Population
• Likelihood Functions
• Models, Genetic
• Algorithms
• Chromosome Mapping
• Cost-Benefit Analysis