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Increasing the efficiency of genomic searches for linkage in complex disorders by DNA pooling of affected sib-pairs.

Molecular psychiatry - 1 Mar 1996

Craddock N, Daniels J, Holmans P, Williams N, Owen M J

Abstract excerpt

Detection of linkage using a systematic genome scan in nuclear families including an affected sibling pair is an important initial step on the path to cloning susceptibility genes for complex genetic disorders such as bipolar disorder and schizophrenia. We describe a novel method in which the pooled genotype of each affected sib-pair is determined and used in the screening stage of a two-stage genome scan. This...

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PMID: 9118316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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