Article
An infrequent point mutation of the p53 gene in human nasopharyngeal carcinoma.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 1992
Sun Y, Hegamyer G, Cheng Y J, Hildesheim A, Chen J Y, Chen I H, Cao Y, Yao K T, Colburn N H
Abstract excerpt
Point mutations in the p53 gene have been detected in a variety of human cancers; the mutations are clustered in four "hot-spots" located in the coding region of exons 5, 7, and 8, which coincide with the four most highly conserved regions of the gene. We report the finding of a heterozygous G---...
Topics
- Base Sequence
- Carcinoma
- Gene Expression
- Genes, p53
- Heterozygote
- Humans
- Molecular Sequence Data
- Mutation
- Nasopharyngeal Neoplasms
- Oligonucleotides
- Polymerase Chain Reaction
- RNA, Neoplasm