Article
p16 gene alterations in nasopharyngeal carcinoma.
Cancer research - 15 May 1995
Lo K W, Huang D P, Lau K M
Abstract excerpt
In order to investigate the p16 gene alterations in nasopharyngeal carcinoma (NPC), we have examined for mutations and deletions of the p16 gene in samples of NPC including 3 cell lines, 3 xenografts, and 20 primary tumors with matched blood DNA as controls. Using single-strand conformation polymorphism and direct sequencing analysis, no p16 gene mutations were detected in the NPC primary tumors and xenografts....
Topics
- Chromosomes, Human, Pair 9
- Gene Deletion
- Genes, Tumor Suppressor
- Homozygote
- Humans
- Mutation
- Nasopharyngeal Neoplasms
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Sequence Analysis, DNA
- Tumor Cells, Cultured