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p53 inactivating mutations in Chinese nasopharyngeal carcinomas.

Cancer letters - 13 Nov 1998

Lung M L, Hu Y, Cheng Y, Li M F, Tang C M, O S K, Iggo R D

Abstract excerpt

Previously a low frequency of p53 mutations was detected in nasopharyngeal carcinoma (NPC) using molecular techniques to screen for mutations, yet immunohistochemical staining revealed a high frequency of p53 aberrant proteins. These findings might be attributed to the occurrence of p53 mutations outside the common hot spots and/or the inactivation of the protein through interactions with cellular or viral...

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PMID: 9929165
DOI: 10.1016/s0304-3835(98)00209-2

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