Alterations of the p53 gene in human primary cervical carcinoma with and without human papillomavirus infection.

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Article

Alterations of the p53 gene in human primary cervical carcinoma with and without human papillomavirus infection.

Cancer research - 1 Oct 1992

Fujita M, Inoue M, Tanizawa O, Iwamoto S, Enomoto T

Abstract excerpt

A previous report using cervical carcinoma cell lines suggests that the inactivation of two tumor suppressor gene products, p53 and pRB, either by complex formation with the E6 and E7 proteins of oncogenic human papillomaviruses (HPVs) or by mutation, may be an important step in cervical carcinogenesis (M. Scheffner et al., Proc. Natl. Acad. Sci. USA, 88: 5523-5527, 1991). The present study was designed to...

Topics

Adenocarcinoma
Base Sequence
Blotting, Southern
Carcinoma, Squamous Cell
DNA, Neoplasm
DNA, Viral
Female
Gene Expression Regulation, Neoplastic
Genes, p53
Genome, Viral
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Molecular Sequence Data

Mutation

Papillomaviridae

Polymorphism, Genetic

Tumor Virus Infections

Uterine Cervical Neoplasms

Source

Open in PubMed

Identifiers

PMID: 1327506

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1327506-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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