Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired clearance of apoptotic cells promotes synergy between atherogenesis and autoimmune disease.

The Journal of experimental medicine - 19 Apr 2004

Aprahamian Tamar, Rifkin Ian, Bonegio Ramon, Hugel Bénédicte, Freyssinet Jean-Marie, Sato Kaori, Castellot John J, Walsh Kenneth

Abstract excerpt

To clarify the link between autoimmune disease and hypercholesterolemia, we created the gld.apoE(-/-) mouse as a model of accelerated atherosclerosis. Atherosclerotic lesion area was significantly increased in gld.apoE(-/-) mice compared with apoE(-/-) mice. gld.apoE(-/-) mice also displayed increases in lymphadenopathy, splenomegaly, and autoantibodies compared with gld mice, and these effects were exacerbated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aorta
Share to Arteriosclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autoimmune Diseases

Share to Cholesterol

Share to Fas Ligand Protein

Share to Hypercholesterolemia

Share to Mice, Inbred C3H

Share to Mice, Mutant Strains

Source

Open in PubMed Open full text

Identifiers

PMID: 15096538
DOI: 10.1084/jem.20031557
PMCID: PMC2211887

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired clearance of apoptotic cells promotes synergy between atherogenesis and autoimmune disease.PMID 15096538Read ↗

Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model.Semantic proximity Read ↗

Accelerated atherosclerosis in ApoE deficient lupus mouse modelsSemantic proximity Read ↗

Lymphocytes are important in early atherosclerosisSemantic proximity Read ↗

Lymphocytes are important in early atherosclerosisSemantic proximity Read ↗

Combined B, T and NK Cell Deficiency Accelerates Atherosclerosis in BALB/c Mice.Semantic proximity Read ↗

T cells expressing the lupus susceptibility allele Pbx1d enhance autoimmunity and atherosclerosis in dyslipidemic mice.Semantic proximity Read ↗

PDZK1 in leukocytes protects against cellular apoptosis and necrotic core development in atherosclerotic plaques in high fat diet fed ldl receptor deficient mice.Semantic proximity Read ↗

Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasomeSemantic proximity Read ↗

Tollip Deficiency Alters Atherosclerosis and Steatosis by Disrupting Lipophagy.Semantic proximity Read ↗

Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice.Semantic proximity Read ↗

Quantitative and qualitative differences in proatherogenic NKT cells in apolipoprotein E-deficient mice.Semantic proximity Read ↗

Phosphatidylserine liposomes mimic apoptotic cells to attenuate atherosclerosis by expanding polyreactive IgM producing B1a lymphocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.