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Article

Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome

31 Mar 2011

Abstract excerpt

The interleukin-1 (IL-1) family of cytokines has been implicated in the pathogenesis of atherosclerosis in previous studies. The NLRP3 inflammasome has recently emerged as a pivotal regulator of IL-1β maturation and secretion by macrophages. Little is currently known about a possible role for the NLRP3 inflammasome in atherosclerosis progression in vivo. We generated ApoE-/- Nlrp3-/-, ApoE-/- Asc-/- and ApoE-/-...

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Identifiers

PMID: 21451572
DOI: 10.1038/cddis.2011.18

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