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Article

T cells expressing the lupus susceptibility allele Pbx1d enhance autoimmunity and atherosclerosis in dyslipidemic mice.

JCI insight - 4 Jun 2020

Li Wei, Elshikha Ahmed S, Cornaby Caleb, Teng Xiangyu, Abboud Georges, Brown Josephine, Zou Xueyang, Zeumer-Spataro Leilani, Robusto Brian, Choi Seung-Chul, Fredenburg Kristianna, Major Amy, Morel Laurence

Abstract excerpt

Patients with systemic lupus erythematosus (SLE) present a high incidence of atherosclerosis, which contributes significantly to morbidity and mortality in this autoimmune disease. An impaired balance between regulatory (Treg) and follicular helper (Tfh) CD4+ T cells is shared by both diseases. However, whether there are common mechanisms of CD4+ T cell dysregulation between SLE and atherosclerosis remains...

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Identifiers

PMID: 32493841
DOI: 10.1172/jci.insight.138274
PMCID: PMC7308052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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