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Article

Tollip Deficiency Alters Atherosclerosis and Steatosis by Disrupting Lipophagy.

Journal of the American Heart Association - 10 Apr 2017

Chen Keqiang, Yuan Ruoxi, Zhang Yao, Geng Shuo, Li Liwu

Abstract excerpt

BACKGROUND: Compromised lipophagy with unknown mechanisms may be critically involved in the intracellular accumulation of lipids, contributing to elevated atherosclerosis and liver steatosis. We hypothesize that toll-interacting protein (Tollip), a key innate immune molecule involved in the fusion of autolysosome, may play a significant role in lipophagy and modulate lipid accumulation during the pathogenesis of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28396568
DOI: 10.1161/JAHA.116.004078
PMCID: PMC5532987

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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