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Article

Disruption of LRP6 in osteoblasts blunts the bone anabolic activity of PTH.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 2013

Li Changjun, Xing Qiujuan, Yu Bing, Xie Hui, Wang Weishan, Shi Chenhui, Crane Janet L, Cao Xu, Wan Mei

Abstract excerpt

Mutations in low-density lipoprotein receptor-related protein 6 (LRP6) are associated with human skeletal disorders. LRP6 is required for parathyroid hormone (PTH)-stimulated signaling pathways in osteoblasts. We investigated whether LRP6 in osteoblasts directly regulates bone remodeling and mediates the bone anabolic effects of PTH by specifically deleting LRP6 in mature osteoblasts in mice (LRP6 KO)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23609180
DOI: 10.1002/jbmr.1962
PMCID: PMC3787713

Genes

LRP6
PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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