Article
Loss of BMP signaling mediated by BMPR1A in osteoblasts leads to differential bone phenotypes in mice depending on anatomical location of the bones.
Bone - 1 Aug 2020
Zhang Honghao, Zhang Yanshuai, Terajima Masahiko, Romanowicz Genevieve, Liu Yangjia, Omi Maiko, Bigelow Erin, Joiner Danese M, Waldorff Erik I, Zhu Peizhi, Raghavan Mekhala, Lynch Michelle, Kamiya Nobuhiro, Zhang Rongqing, Jepsen Karl J, Goldstein Steve, Morris Michael D, Yamauchi Mitsuo, Kohn David H, Mishina Yuji
Abstract excerpt
Bone morphogenetic protein (BMP) signaling in osteoblasts plays critical roles in skeletal development and bone homeostasis. Our previous studies showed loss of function of BMPR1A, one of the type 1 receptors for BMPs, in osteoblasts results in increased trabecular bone mass in long bones due to an imbalance between bone formation and bone resorption. Decreased bone resorption was associated with an increased...
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