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Article

Mineralization and bone resorption are regulated by the androgen receptor in male mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2009

Chiang Cherie, Chiu Maria, Moore Alison J, Anderson Paul H, Ghasem-Zadeh Ali, McManus Julie F, Ma Cathy, Seeman Ego, Clemens Thomas L, Morris Howard A, Zajac Jeffrey D, Davey Rachel A

Abstract excerpt

Androgens play a key role in skeletal growth and bone maintenance; however, their mechanism of action remains unclear. To address this, we selectively deleted the androgen receptor (AR) in terminally differentiated, mineralizing osteoblasts using the Cre/loxP system in mice (osteocalcin-Cre AR knockouts [mOBL-ARKOs]). Male mOBL-ARKOs had decreased femoral trabecular bone volume compared with littermate controls...

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PMID: 19049333
DOI: 10.1359/jbmr.081217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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