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Article

Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization.

The Journal of biological chemistry - 15 Nov 2002

Zhang Mei, Xuan Shouhong, Bouxsein Mary L, von Stechow Dietrich, Akeno Nagako, Faugere Marie Claude, Malluche Hartmut, Zhao Guisheng, Rosen Clifford J, Efstratiadis Argiris, Clemens Thomas L

Abstract excerpt

To examine the local actions of IGF signaling in skeletal tissue in a physiological context, we have used Cre-mediated recombination to disrupt selectively in mouse osteoblasts the gene encoding the type 1 IGF receptor (Igf1r). Mice carrying this bone-specific mutation were of normal size and weight but, in comparison with normal siblings, demonstrated a striking decrease in cancellous bone volume, connectivity,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12215457
DOI: 10.1074/jbc.M208265200

Genes

IGF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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