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Article

Activin receptor type 2A (ACVR2A) functions directly in osteoblasts as a negative regulator of bone mass.

The Journal of biological chemistry - 18 Aug 2017

Goh Brian C, Singhal Vandana, Herrera Angelica J, Tomlinson Ryan E, Kim Soohyun, Faugere Marie-Claude, Germain-Lee Emily L, Clemens Thomas L, Lee Se-Jin, DiGirolamo Douglas J

Abstract excerpt

Bone and skeletal muscle mass are highly correlated in mammals, suggesting the existence of common anabolic signaling networks that coordinate the development of these two anatomically adjacent tissues. The activin signaling pathway is an attractive candidate to fulfill such a role. Here, we generated mice with conditional deletion of activin receptor (ACVR) type 2A, ACVR2B, or both, in osteoblasts, to determine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28659341
DOI: 10.1074/jbc.M117.782128
PMCID: PMC5566533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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