Inhibition of cellular proteasome activities enhances hepadnavirus replication in an HBX-dependent manner.

doi:10.1128/jvi.78.9.4566-4572.2004

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Article

Inhibition of cellular proteasome activities enhances hepadnavirus replication in an HBX-dependent manner.

Journal of virology - 1 May 2004

Zhang Zhensheng, Protzer Ulrike, Hu Zongyi, Jacob James, Liang T Jake

Abstract excerpt

The X protein (HBX) of the hepatitis B virus (HBV) is not essential for the HBV life cycle in vitro but is important for productive infection in vivo. Our previous study suggests that interaction of HBX with the proteasome complex may underlie the pleiotropic functions of HBX. With the woodchuck model, we demonstrated that the X-deficient mutants of woodchuck hepatitis virus (WHV) are not completely replication...

Topics

Adenoviridae
Animals
Baculoviridae
Calcium Signaling
Cysteine Endopeptidases
Hepadnaviridae
Hepatitis B Virus, Woodchuck
Hepatitis B virus
Humans
Multienzyme Complexes
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proteasome Endopeptidase Complex

Recombination, Genetic

Trans-Activators

Tumor Cells, Cultured

Viral Regulatory and Accessory Proteins

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 15078938
DOI: 10.1128/jvi.78.9.4566-4572.2004
PMCID: PMC387701

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