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Article

X-deficient woodchuck hepatitis virus mutants behave like attenuated viruses and induce protective immunity in vivo.

The Journal of clinical investigation - 1 Nov 2001

Zhang Z, Torii N, Hu Z, Jacob J, Liang T J

Abstract excerpt

The X protein (HBX) of the hepatitis B virus (HBV) has been shown to be important for the establishment of HBV infection in vivo. Our previous studies suggested that interaction of HBX with the proteasome complex may underlie the pleiotropic functions of HBX. In this study, we generated a series of woodchuck hepatitis virus (WHV) X mutants, including mutants of the domain interacting with the proteasome, and...

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Identifiers

PMID: 11714744
DOI: 10.1172/JCI13787
PMCID: PMC209423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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