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HBx protein is indispensable for development of viraemia in human hepatocyte chimeric mice

10 Mar 2010

Abstract excerpt

The non-structural X protein, HBx, of hepatitis B virus (HBV) is assumed to play an important role in HBV replication. Woodchuck hepatitis virus X protein is indispensable for virus replication, but the duck hepatitis B virus X protein is not. In this study, we investigated whether the HBx protein is indispensable for HBV replication in vivo using human hepatocyte chimeric mice. HBx-deficient (HBx-def) HBV was...

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PMID: 20219897
DOI: 10.1099/vir.0.019224-0

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