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Enhancement of Hepatitis B Virus Replication by the Regulatory X Protein In Vitro and In Vivo

21 Dec 2006

Abstract excerpt

The 3.2-kb hepatitis B virus (HBV) genome encodes a single regulatory protein termed HBx. While multiple functions have been identified for HBx in cell culture, its role in virus replication remains undefined. In the present study, we combined an HBV plasmid-based replication assay with the hydrodynamic tail vein injection model to investigate the function(s) of HBx in vivo. Using a greater-than-unit-length HBV...

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Identifiers

PMID: 17182675
DOI: 10.1128/jvi.02020-06

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