Article
Hepatitis B virus X protein stimulates viral genome replication via a DDB1-dependent pathway distinct from that leading to cell death.
Journal of virology - 1 Apr 2005
Leupin Olivier, Bontron Séverine, Schaeffer Céline, Strubin Michel
Abstract excerpt
The hepatitis B virus (HBV) X protein (HBx) is essential for virus infection and has been implicated in the development of liver cancer associated with chronic infection. HBx can interact with a number of cellular proteins, and in cell culture, it exhibits pleiotropic activities, among which is its ability to interfere with cell viability and stimulate HBV replication. Previous work has demonstrated that HBx...
Topics
- Amino Acid Substitution
- Cell Death
- Cell Line, Tumor
- Cell Nucleus
- DNA Replication
- DNA, Viral
- DNA-Binding Proteins
- Genome, Viral
- Hepatitis B virus
- Humans
- Mutation
- Point Mutation
- Protein Binding
- RNA, Messenger