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Mechanism of inhibiting type I interferon induction by hepatitis B virus X protein

1 Dec 2010

Abstract excerpt

Hepatitis B virus (HBV) is regarded as a stealth virus, invading and replicating efficiently in human liver undetected by host innate antiviral immunity. Here, we show that type I interferon (IFN) induction but not its downstream signaling is blocked by HBV replication in HepG2.2.15 cells. This effect may be partially due to HBV X protein (HBx), which impairs IFNβ promoter activation by both Sendai virus (SeV)...

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PMID: 21213104
DOI: 10.1007/s13238-010-0141-8

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