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A DNA polymerase β mutant from colon cancer cells induces mutations

9 Apr 2004

Abstract excerpt

Previous investigations have shown that approximately 35% of the 90 tumors analyzed to date contain mutations within the DNA polymerasebeta (pol beta) gene. The existence of pol beta mutations in a substantial fraction of human tumors studied suggests a link between DNA pol beta and cancer. A DNA pol beta variant, in which Lys-289 has been altered to Met, was identified previously in a colorectal carcinoma. The...

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PMID: 15075389
DOI: 10.1073/pnas.0308571101

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