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Article

Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation.

The Journal of biological chemistry - 6 Jul 2012

Nemec Antonia A, Donigan Katherine A, Murphy Drew L, Jaeger Joachim, Sweasy Joann B

Abstract excerpt

Rapidly advancing technology has resulted in the generation of the genomic sequences of several human tumors. We have identified several mutations of the DNA polymerase β (pol β) gene in human colorectal cancer. We have demonstrated that the expression of the pol β G231D variant increased chromosomal aberrations and induced cellular transformation. The transformed phenotype persisted in the cells even once the...

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Source

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Identifiers

PMID: 22573322
DOI: 10.1074/jbc.M112.362111
PMCID: PMC3390657

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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