The S229L colon tumor-associated variant of DNA polymerase β induces cellular transformation as a result of decreased polymerization efficiency.

doi:10.1074/jbc.M114.550400

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Article

The S229L colon tumor-associated variant of DNA polymerase β induces cellular transformation as a result of decreased polymerization efficiency.

The Journal of biological chemistry - 16 May 2014

Nemec Antonia A, Murphy Drew L, Donigan Katherine A, Sweasy Joann B

Abstract excerpt

DNA polymerase β (Pol β) plays a key role in base excision repair (BER) by filling in small gaps that are generated after base adducts are excised from the DNA. Pol β is mutated in a large number of colorectal tumors, and these mutations may drive carcinogenesis. In the present study, we wished to determine whether the S229L somatic Pol β variant identified in a stage 3 colorectal tumor is a driver of...

Topics

Animals
Base Sequence
Carcinogenesis
Cell Line
Cell Transformation, Neoplastic
Chromosome Aberrations
Colonic Neoplasms
DNA
DNA Polymerase beta
DNA Repair
Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genomic Instability

Humans

Kinetics

Mice

Mutation

Neoplasm Staging

Nucleotides

Source

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Identifiers

PMID: 24668809
DOI: 10.1074/jbc.M114.550400
PMCID: PMC4022845

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