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Article

Hinge residue Ile260 of DNA polymerase beta is important for enzyme activity and fidelity.

Biochemistry - 15 Mar 2005

Starcevic Daniela, Dalal Shibani, Sweasy Joann

Abstract excerpt

DNA polymerases ensure efficient insertion of the correct dNTP into the DNA substrate. They have evolved mechanisms for discriminating among very similar dNTP substrates. DNA polymerase beta is a repair polymerase that provides a model system for a direct study of insertion fidelity. In this study, we examined the role of hinge residue Ile260 of the rat Polbeta on enzyme activity and accuracy. We changed residue...

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Identifiers

PMID: 15751954
DOI: 10.1021/bi047956x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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