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Article

Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation.

Proceedings of the National Academy of Sciences of the United States of America - 4 Oct 2005

Sweasy Joann B, Lang Tieming, Starcevic Daniela, Sun Ka-Wai, Lai Char-Chang, Dimaio Daniel, Dalal Shibani

Abstract excerpt

Thirty percent of the 189 tumors studied to date express DNA polymerase beta variants. One of these variants was identified in a prostate carcinoma and is altered from isoleucine to methionine at position 260, within the hydrophobic hinge region of the protein. Another variant was identified in a colon carcinoma and is altered at position 289 from lysine to methionine, within helix N of the protein. We have shown...

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Identifiers

PMID: 16179390
DOI: 10.1073/pnas.0505166102
PMCID: PMC1242307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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