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Article

Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator.

Biochemistry - 6 Dec 2005

Dalal Shibani, Hile Suzanne, Eckert Kristin A, Sun Ka-wai, Starcevic Daniela, Sweasy Joann B

Abstract excerpt

Studies show that 30% of 189 tumors sequenced to date express variants of the polymerase beta (pol beta) protein that are not present in normal tissue. This raises the possibility that variants of pol beta might be linked to the etiology of cancer. Here, we characterize the I260M prostate-cancer-associated variant of pol beta. Ile260 is a key residue of the hydrophobic hinge that is important for the closing of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16313169
DOI: 10.1021/bi051179z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator.PMID 16313169Read ↗

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