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Article

A genetic system to identify DNA polymerase beta mutator mutants.

Proceedings of the National Academy of Sciences of the United States of America - 18 Feb 1997

Washington S L, Yoon M S, Chagovetz A M, Li S X, Clairmont C A, Preston B D, Eckert K A, Sweasy J B

Abstract excerpt

DNA polymerase beta (pol beta) is a 39-kDa protein that functions in DNA repair processes in mammalian cells. As a first step toward understanding mechanisms of polymerase fidelity, we developed a genetic method to identify mammalian pol beta mutator mutants. This screen takes advantage of a microbial genetics assay and the ability of rat pol beta to substitute for Escherichia coli DNA polymerase I in DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9037051
DOI: 10.1073/pnas.94.4.1321
PMCID: PMC19789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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