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Article

Investigating the putative glycine hinge in Shaker potassium channel.

The Journal of general physiology - 1 Sept 2005

Ding Shinghua, Ingleby Lindsey, Ahern Christopher A, Horn Richard

Abstract excerpt

The crystal structure of an open potassium channel reveals a kink in the inner helix that lines the pore (Jiang, Y.X., A. Lee, J.Y. Chen, M. Cadene, B.T. Chait, and R. MacKinnon. 2002. Nature 417:523-526). The putative hinge point is a highly conserved glycine residue. We examined the role of the homologous residue (Gly466) in the S6 transmembrane segment of Shaker potassium channels. The nonfunctional alanine...

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Identifiers

PMID: 16103276
DOI: 10.1085/jgp.200509287
PMCID: PMC2266578

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigating the putative glycine hinge in Shaker potassium channel.PMID 16103276Read ↗

Gating of shaker-type channels requires the flexibility of S6 caused by prolines.Semantic proximity Read ↗

Topology of the Shaker potassium channel probed with hydrophilic epitope insertions.Semantic proximity Read ↗

Electrostatic interactions between transmembrane segments mediate folding of Shaker K+ channel subunits.Semantic proximity Read ↗

A highly conserved alanine in the S6 domain of the hERG1 K+ channel is required for normal gating.Semantic proximity Read ↗

Nonsensing residues in S3-S4 linker's C terminus affect the voltage sensor set point in K+ channels.Semantic proximity Read ↗

Functional interactions at the interface between voltage-sensing and pore domains in the Shaker K(v) channel.Semantic proximity Read ↗

Atomic proximity between S4 segment and pore domain in Shaker potassium channels.Semantic proximity Read ↗

Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel.Semantic proximity Read ↗

Tail end of the s6 segment: role in permeation in shaker potassium channels.Semantic proximity Read ↗

Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channels.Semantic proximity Read ↗

S4 mutations alter the single-channel gating kinetics of Shaker K+ channels.Semantic proximity Read ↗

Role of hydrophobic and ionic forces in the movement of S4 of the Shaker potassium channel.Semantic proximity Read ↗

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