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Article

Sorting of mannose 6-phosphate receptors mediated by the GGAs.

Science (New York, N.Y.) - 1 Jun 2001

Puertollano R, Aguilar R C, Gorshkova I, Crouch R J, Bonifacino J S

Abstract excerpt

The delivery of soluble hydrolases to lysosomes is mediated by the cation-independent and cation-dependent mannose 6-phosphate receptors. The cytosolic tails of both receptors contain acidic-cluster-dileucine signals that direct sorting from the trans-Golgi network to the endosomal-lysosomal system. We found that these signals bind to the VHS domain of the Golgi-localized, gamma-ear-containing, ARF-binding...

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Identifiers

PMID: 11387475
DOI: 10.1126/science.1060750

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Sorting of mannose 6-phosphate receptors mediated by the GGAs.PMID 11387475Read ↗

Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins.Semantic proximity Read ↗

Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor.Semantic proximity Read ↗

Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network.Semantic proximity Read ↗

The acidic cluster of the CK2 site of the cation-dependent mannose 6-phosphate receptor (CD-MPR) but not its phosphorylation is required for GGA1 and AP-1 binding.Semantic proximity Read ↗

Lysosomal and vacuolar sorting: not so different after all!Semantic proximity Read ↗

Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes.Semantic proximity Read ↗

The palmitoyltransferase of the cation-dependent mannose 6-phosphate receptor cycles between the plasma membrane and endosomes.Semantic proximity Read ↗

Vacuolar Protein Sorting Receptor in Giardia lambliaSemantic proximity Read ↗

Sorting receptor SORLA: cellular mechanisms and implications for disease.Semantic proximity Read ↗

Lysosomal hydrolase mannose 6-phosphate uncovering enzyme resides in the trans-Golgi network.Semantic proximity Read ↗

The cytoplasmic tail of the mannose 6-phosphate/insulin-like growth factor-II receptor has two signals for lysosomal enzyme sorting in the Golgi.Semantic proximity Read ↗

Phosphorylation-induced conformational changes regulate GGAs 1 and 3 function at the trans-Golgi network.Semantic proximity Read ↗

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