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Article

AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1.

EMBO reports - 1 Dec 2003

Hinners Ina, Wendler Franz, Fei Hao, Thomas Laurel, Thomas Gary, Tooze Sharon A

Abstract excerpt

The R-SNARE VAMP4, which contains a dileucine motif, binds to the AP-1 (adaptor protein-1) subunit mu 1a, but not mu 1b, or the GGAs (Golgi-associated gamma ear containing ARF binding proteins). Serine 20 and leucines 25,26 are essential for this binding. AP-1 association with VAMP4 is enhanced when serine 30, in an acidic cluster, is phosphorylated by casein kinase 2. This phosphorylation-dependent modulation of...

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Share to Adaptor Proteins, Vesicular Transport
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14608369
DOI: 10.1038/sj.embor.7400018
PMCID: PMC1326413

Genes

VAMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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