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Article

Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins.

The Journal of biological chemistry - 24 May 2002

Doray Balraj, Bruns Kerry, Ghosh Pradipta, Kornfeld Stuart

Abstract excerpt

The GGAs (Golgi-localizing, gamma-adaptin ear homology domain, ARF-binding) are a multidomain family of proteins implicated in protein trafficking between the Golgi and endosomes. Recent evidence has established that the cation-independent (CI) and cation-dependent (CD) mannose 6-phosphate receptors (MPRs) bind specifically to the VHS domains of the GGAs through acidic cluster-dileucine motifs at the carboxyl...

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Identifiers

PMID: 11886874
DOI: 10.1074/jbc.M201879200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins.PMID 11886874Read ↗

Sorting of mannose 6-phosphate receptors mediated by the GGAs.Semantic proximity Read ↗

The acidic cluster of the CK2 site of the cation-dependent mannose 6-phosphate receptor (CD-MPR) but not its phosphorylation is required for GGA1 and AP-1 binding.Semantic proximity Read ↗

Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor.Semantic proximity Read ↗

Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network.Semantic proximity Read ↗

GGA1 interacts with the adaptor protein AP-1 through a WNSF sequence in its hinge region.Semantic proximity Read ↗

Characterization of the endosomal sorting signal of the cation-dependent mannose 6-phosphate receptor.Semantic proximity Read ↗

ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization.Semantic proximity Read ↗

EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking.Semantic proximity Read ↗

Plasma membrane and nuclear localization of G protein coupled receptor kinase 6A.Semantic proximity Read ↗

A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome.Semantic proximity Read ↗

The palmitoyltransferase of the cation-dependent mannose 6-phosphate receptor cycles between the plasma membrane and endosomes.Semantic proximity Read ↗

ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) Have Both Specific and Shared EffectorsSemantic proximity Read ↗

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