Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3.

Molecular and cellular biology - 1 Apr 2004

Cheng Hailing, He Xiaoyuan, Moore Claire

Abstract excerpt

Swd2, an essential WD repeat protein in Saccharomyces cerevisiae, is a component of two very different complexes: the cleavage and polyadenylation factor CPF and the Set1 methylase, which modifies lysine 4 of histone H3 (H3-K4). It was not known if Swd2 is important for the function of either of these entities. We show here that, in extract from cells depleted of Swd2, cleavage and polyadenylation of the mRNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Histone-Lysine N-Methyltransferase
Share to Histones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lysine

Share to Methylation

Share to RNA-Binding Proteins

Share to RNA Polymerase II

Share to Saccharomyces cerevisiae Proteins

Share to Temperature

Source

Open in PubMed Open full text

Identifiers

PMID: 15024081
DOI: 10.1128/MCB.24.7.2932-2943.2004
PMCID: PMC371121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3.PMID 15024081Read ↗

Yeast Swd2 is essential because of antagonism between Set1 histone methyltransferase complex and APT (associated with Pta1) termination factor.Semantic proximity Read ↗

H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway.Semantic proximity Read ↗

SETD2 methyltransferase activity promotes correct transcription initiation and termination.Semantic proximity Read ↗

Setd2 regulates quiescence and differentiation of adult hematopoietic stem cells by restricting RNA polymerase II elongation.Semantic proximity Read ↗

SETD2 methyltransferase activity aids gene definition by promoting correct transcription initiation and terminationSemantic proximity Read ↗

Sif2p interacts with Sir4p amino-terminal domain and antagonizes telomeric silencing in yeast.Semantic proximity Read ↗

Spliceosome-mediated decay (SMD) regulates expression of nonintronic genes in budding yeast.Semantic proximity Read ↗

A Requirement for the Saccharomyces cerevisiae Paf1 complex in snoRNA 3' end formation.Semantic proximity Read ↗

Positive roles of SAS2 in DNA replication and transcriptional silencing in yeast.Semantic proximity Read ↗

H3K4 Methylation Dependent and Independent Chromatin Regulation by JHD2 and SET1 in Budding Yeast.Semantic proximity Read ↗

Association of the histone methyltransferase Set2 with RNA polymerase II plays a role in transcription elongation.Semantic proximity Read ↗

Stress-induced nuclear RNA degradation pathways regulate yeast bromodomain factor 2 to promote cell survival.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.