Article

SETD2 methyltransferase activity aids gene definition by promoting correct transcription initiation and termination

2025-07-15

Abstract excerpt

SETD2 is a methyltransferase responsible for depositing histone H3 lysine 36 trimethylation (H3K36me3). Loss of its enzymatic activity occurs in some cancers, including renal cell carcinoma (RCC). In RCC, SETD2 mutations have been linked to delayed transcription termination, but not explored in depth. Here, using nascent transcriptomics in SETD2 knockout and patient-derived cells, we reveal a dichotomy in SETD2 fu...

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Literature Corpus work: b7d8fc09-2c90-5b69-8b3b-e22cd94464c2
DOI: 10.1101/2025.07.14.664659

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