Article
Stress-induced nuclear RNA degradation pathways regulate yeast bromodomain factor 2 to promote cell survival.
PLoS genetics - 1 Sept 2014
Roy Kevin, Chanfreau Guillaume
Abstract excerpt
Bromodomain proteins are key regulators of gene expression. How the levels of these factors are regulated in specific environmental conditions is unknown. Previous work has established that expression of yeast Bromodomain factor 2 (BDF2) is limited by spliceosome-mediated decay (SMD). Here we show that BDF2 is subject to an additional layer of post-transcriptional control through RNase III-mediated decay (RMD)....
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