Article
Association of the histone methyltransferase Set2 with RNA polymerase II plays a role in transcription elongation.
The Journal of biological chemistry - 20 Dec 2002
Li Jiaxu, Moazed Danesh, Gygi Steven P
Abstract excerpt
The Saccharomyces cerevisiae protein, Set2, has recently been shown to be a histone methyltransferase. To elucidate the function of Set2, its associated proteins were identified using tandem affinity purification and mass spectrometry. We found that Set2 associates with RNA polymerase II. The interaction between the Set2 protein and RNA polymerase II requires the WW domain in Set2 and phosphorylation of the...
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