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Article

Sif2p interacts with Sir4p amino-terminal domain and antagonizes telomeric silencing in yeast.

Current biology : CB - 18 Jun 1998

Cockell M, Renauld H, Watt P, Gasser S M

Abstract excerpt

Several regions of the Saccharomyces cerevisiae genome are subject to position-dependent transcriptional repression mediated by a multi-component nucleosome-binding complex of silent information regulator proteins (Sir2p, Sir3p and Sir4p). These proteins are present in limiting amounts in the nucleus and are targeted to specific chromosomal regions by interaction with sequence-specific DNA-binding factors....

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PMID: 9651685
DOI: 10.1016/s0960-9822(98)70304-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Sif2p interacts with Sir4p amino-terminal domain and antagonizes telomeric silencing in yeast.PMID 9651685Read ↗

Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p.Semantic proximity Read ↗

Locus specificity determinants in the multifunctional yeast silencing protein Sir2.Semantic proximity Read ↗

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.Semantic proximity Read ↗

Sumoylation of Sir2 differentially regulates transcriptional silencing in yeast.Semantic proximity Read ↗

SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast.Semantic proximity Read ↗

RLF2, a subunit of yeast chromatin assembly factor-I, is required for telomeric chromatin function in vivo.Semantic proximity Read ↗

A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors.Semantic proximity Read ↗

SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres.Semantic proximity Read ↗

Two classes of sir3 mutants enhance the sir1 mutant mating defect and abolish telomeric silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Hyperactivation of the silencing proteins, Sir2p and Sir3p, causes chromosome loss.Semantic proximity Read ↗

A region of the nucleosome required for multiple types of transcriptional silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

The SCFDia2 ubiquitin E3 ligase ubiquitylates Sir4 and functions in transcriptional silencing.Semantic proximity Read ↗

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