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Article

Spliceosome-mediated decay (SMD) regulates expression of nonintronic genes in budding yeast.

Genes & development - 15 Sept 2013

Volanakis Adam, Passoni Monica, Hector Ralph D, Shah Sneha, Kilchert Cornelia, Granneman Sander, Vasiljeva Lidia

Abstract excerpt

We uncovered a novel role for the spliceosome in regulating mRNA expression levels that involves splicing coupled to RNA decay, which we refer to as spliceosome-mediated decay (SMD). Our transcriptome-wide studies identified numerous transcripts that are not known to have introns but are spliced by the spliceosome at canonical splice sites in Saccharomyces cerevisiae. Products of SMD are primarily degraded by the...

Topics

Gene Expression Regulation, Fungal
Mutation
Phenotype
RNA
RNA Splicing
RNA Stability
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Spliceosomes
Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24065768
DOI: 10.1101/gad.221960.113
PMCID: PMC3792478

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