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Article

Spliceosome-mediated decay (SMD) regulates expression of nonintronic genes in budding yeast.

Genes & development - 15 Sept 2013

Volanakis Adam, Passoni Monica, Hector Ralph D, Shah Sneha, Kilchert Cornelia, Granneman Sander, Vasiljeva Lidia

Abstract excerpt

We uncovered a novel role for the spliceosome in regulating mRNA expression levels that involves splicing coupled to RNA decay, which we refer to as spliceosome-mediated decay (SMD). Our transcriptome-wide studies identified numerous transcripts that are not known to have introns but are spliced by the spliceosome at canonical splice sites in Saccharomyces cerevisiae. Products of SMD are primarily degraded by the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 24065768
DOI: 10.1101/gad.221960.113
PMCID: PMC3792478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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