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Article

SETD2 methyltransferase activity promotes correct transcription initiation and termination.

EMBO reports - 1 May 2026

Kopczyńska Magda, Nakayama Chihiro, Stępień Agata, Ito Shoko, Imami Koshi, Gdula Michał R, Nojima Takayuki, Kamieniarz-Gdula Kinga

Abstract excerpt

SETD2 is a methyltransferase responsible for depositing histone H3 lysine 36 trimethylation (H3K36me3). Loss of its enzymatic activity occurs in some cancers, including renal cell carcinoma. SETD2 mutations have been linked to delayed transcription termination but have not been explored in depth. Here, using nascent transcriptomics in SETD2 knockout and patient-derived cells, we reveal a dichotomy in SETD2...

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Source

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Identifiers

PMID: 41872549
DOI: 10.1038/s44319-026-00744-1
PMCID: PMC13172057

Genes

SETD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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