SETD2 methyltransferase activity promotes correct transcription initiation and termination.

doi:10.1038/s44319-026-00744-1

Article

SETD2 methyltransferase activity promotes correct transcription initiation and termination.

EMBO reports - 1 May 2026

Kopczyńska Magda, Nakayama Chihiro, Stępień Agata, Ito Shoko, Imami Koshi, Gdula Michał R, Nojima Takayuki, Kamieniarz-Gdula Kinga

Abstract excerpt

SETD2 is a methyltransferase responsible for depositing histone H3 lysine 36 trimethylation (H3K36me3). Loss of its enzymatic activity occurs in some cancers, including renal cell carcinoma. SETD2 mutations have been linked to delayed transcription termination but have not been explored in depth....

Topics

Histone-Lysine N-Methyltransferase
Humans
Transcription Initiation, Genetic
Histones
Transcription Termination, Genetic
Transcription, Genetic
Polyadenylation
Mutation

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