Constitutive expression of exogenous myc in myelomonocytic cells: acquisition of a more transformed phenotype and inhibition of differentiation induction.

Article

Constitutive expression of exogenous myc in myelomonocytic cells: acquisition of a more transformed phenotype and inhibition of differentiation induction.

Oncogene - 1 Sept 1992

Chisholm O, Stapleton P, Symonds G

Abstract excerpt

The effects of deregulated expression of the human c-myc and MC29 v-myc oncogenes have been examined in a murine myelomonocytic cell line J774 (c-myc) and in a variety of myelomonocytic cell lines of different degrees of maturity generated from primary hematopoietic tissue (v-myc). Introduction o...

Topics

Animals
Cell Differentiation
Cell Line
Cell Transformation, Neoplastic
Gene Expression
Gene Expression Regulation, Neoplastic
Genes, myc
Hematopoietic Stem Cells
Mice
Monocytes
Phenotype

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