Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells

5 Mar 2019

Abstract excerpt

BACKGROUND: Mesenchymal stromal cells isolated from bone marrow (MSC) represent an attractive source of adult stem cells for regenerative medicine. However, thorough research is required into their clinical application safety issues concerning a risk of potential neoplastic degeneration in a process of MSC propagation in cell culture for therapeutic applications. Expansion protocols could preselect MSC with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Joint Diseases
Share to Bone Tissue Engineering Materials
Share to Mesenchymal stem cell research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30836996
DOI: 10.1186/s13287-019-1187-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cellsPMID 30836996Read ↗

Generation of Osteosarcomas from a Combination of Rb Silencing and c-Myc Overexpression in Human Mesenchymal Stem Cells.Semantic proximity Read ↗

Molecular Characterization of Spontaneous Mesenchymal Stem Cell TransformationSemantic proximity Read ↗

Rat bone marrow mesenchymal stem cells undergo malignant transformation via indirect co-cultured with tumour cells.Semantic proximity Read ↗

Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation.Semantic proximity Read ↗

Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation.Semantic proximity Read ↗

Various lamin A/C mutations alter expression profile of mesenchymal stem cells in mutation specific manner.Semantic proximity Read ↗

Notch2 Signaling Regulates the Proliferation of Murine Bone Marrow-Derived Mesenchymal Stem/Stromal Cells via c-Myc ExpressionSemantic proximity Read ↗

Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathwaySemantic proximity Read ↗

Immortalization of bone marrow-derived human mesenchymal stem cells by removable simian virus 40T antigen gene: analysis of the ability to support expansion of cord blood hematopoietic progenitor cells.Semantic proximity Read ↗

c-Fos induces chondrogenic tumor formation in immortalized human mesenchymal progenitor cellsSemantic proximity Read ↗

Myc oncogenes: the enigmatic familySemantic proximity Read ↗

Assessment of Tumorigenic Potential in Mesenchymal-Stem/Stromal-Cell-Derived Small Extracellular Vesicles (MSC-sEV)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.