Neoplastic transformation and tumorigenesis by the human protooncogene MYC.

doi:10.1073/pnas.87.6.2102

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Article

Neoplastic transformation and tumorigenesis by the human protooncogene MYC.

Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 1990

Ramsay G M, Moscovici G, Moscovici C, Bishop J M

Abstract excerpt

Damage to the protooncogene MYC has been implicated in the genesis of diverse human tumors, but the tumorigenic potential of the isolated gene has been disputed. Here we report the use of a retroviral vector to test the potency of human MYC for neoplastic transformation in avian cells. We found that sustained and abundant expression of MYC can transform both embryonic fibroblasts and hematopoietic cells and...

Topics

Actins
Animals
Avian Sarcoma Viruses
Cell Division
Cell Transformation, Neoplastic
Cells, Cultured
Chickens
Fibroblasts
Fibronectins
Fluorescent Antibody Technique
Genetic Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Phenotype

Protein-Tyrosine Kinases

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-myc

Proto-Oncogenes

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 2156260
DOI: 10.1073/pnas.87.6.2102
PMCID: PMC53634

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2156260-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Neoplastic transformation and tumorigenesis by the human protooncogene MYC.PMID 2156260Read ↗

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