Abnormal regulation of the myc gene in myeloid leukemia.

doi:10.1007/BF02987745

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Article

Abnormal regulation of the myc gene in myeloid leukemia.

Medical oncology and tumor pharmacotherapy - 1 Jan 1992

Gopal V, Kadam P, Preisler H, Hulette B, Li Y Q, Steele P, Freeman J, Banavali S

Abstract excerpt

To study the regulation of expression of the myc protooncogene, cells from normal individuals and patients with acute myelogenous leukemia (AML), and chronic phase and blastic crisis of chronic myeloid leukemia (CML) cells were put in overnight culture in the presence or absence of fetal calf serum. Myc expression in normal marrow cells and chronic phase CML cells fell after culture in vitro. In contrast, myc...

Topics

Base Sequence
Blast Crisis
Blotting, Southern
Bone Marrow Cells
Cell Count
Gene Expression Regulation, Leukemic
Genes, myc
Genes, ras
Humans
Interferon alpha-2
Interferon-alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Leukemia, Myeloid, Acute

Molecular Sequence Data

Mutation

RNA, Neoplasm

Recombinant Proteins

Tretinoin

Source

Open in PubMed

Identifiers

PMID: 1341325
DOI: 10.1007/BF02987745

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1341325-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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