Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CR1/CR2 interactions modulate the functions of the cell surface epidermal growth factor receptor.

The Journal of biological chemistry - 21 May 2004

Walker Francesca, Orchard Suzanne G, Jorissen Robert N, Hall Nathan E, Zhang Hui-Hua, Hoyne Peter A, Adams Timothy E, Johns Terrance G, Ward Colin, Garrett Thomas P J, Zhu Hong-Jian, Nerrie Maureen, Scott Andrew M, Nice Edouard C, Burgess Antony W

Abstract excerpt

Recent crystallographic data on the isolated extracellular domain of the epidermal growth factor receptor (EGFR) have suggested a model for its activation by ligand. We have tested this model in the context of the full-length EGFR displayed at the cell surface, by introducing mutations in two regions (CR1 and CR2) of the extracellular domain thought to be critical for regulation of receptor activation. Mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cross-Linking Reagents
Share to Dimerization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epidermal Growth Factor

Share to Ligands

Share to MAP Kinase Signaling System

Share to Protein Structure, Secondary

Share to Protein-Tyrosine Kinases

Share to Tyrosine

Source

Identifiers

PMID: 15016810
DOI: 10.1074/jbc.M401244200

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CR1/CR2 interactions modulate the functions of the cell surface epidermal growth factor receptor.PMID 15016810Read ↗

EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization.Semantic proximity Read ↗

The EGF receptor Hokey-Cokey.Semantic proximity Read ↗

The insulin and EGF receptor structures: new insights into ligand-induced receptor activation.Semantic proximity Read ↗

Activation of the EGF Receptor by Ligand Binding and Oncogenic Mutations: The “Rotation Model”Semantic proximity Read ↗

Activation of preformed EGF receptor dimers by ligand-induced rotation of the transmembrane domain.Semantic proximity Read ↗

A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptorSemantic proximity Read ↗

Mechanisms of epidermal growth factor receptor signaling as characterized by patterned ligand activation and mutational analysis.Semantic proximity Read ↗

Binding of single-mutant epidermal growth factor (EGF) ligands alters the stability of the EGF receptor dimer and promotes growth signaling.Semantic proximity Read ↗

Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor.Semantic proximity Read ↗

Mechanisms for kinase-mediated dimerization of the epidermal growth factor receptor.Semantic proximity Read ↗

Activation of the EGF Receptor by Ligand Binding and Oncogenic Mutations: The “Rotation Model”Semantic proximity Read ↗

A model for the activation of the epidermal growth factor receptor kinase involvement of an asymmetric dimer?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.