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Article

The insulin and EGF receptor structures: new insights into ligand-induced receptor activation.

Trends in biochemical sciences - 1 Mar 2007

Ward Colin W, Lawrence Michael C, Streltsov Victor A, Adams Timothy E, McKern Neil M

Abstract excerpt

The insulin receptor (IR) and epidermal growth factor receptor (EGFR; also known as ErbB) families exhibit similarities in the composition of their ectodomains. The past five years have seen structures determined for all members of the EGFR family including some complexes with ligand or monoclonal antibody fragments. These structures have led to a clearer understanding of their mechanism of activation and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17280834
DOI: 10.1016/j.tibs.2007.01.001

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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