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Numerical aberrations of chromosome 17 and the p53 locus in small hepatocellular carcinomas.

Anticancer research - 1 Jan 2000

Yano Hiroshi, Nanashima Atsushi, Hidaka Shigekazu, Haseba Masatoshi, Tanaka Kenji, Yamaguchi Hiroyuki, Nakagoe Tohru, Tagawa Yutaka, Nagayasu Takeshi

Abstract excerpt

To investigate numerical aberrations of chromosome 17 and the p53 locus in early stages of hepatocellular carcinoma (HCC), 12 fresh-frozen specimens of small HCCs (less than 30 mm in size) were examined by dual-color fluorescence in situ hybridization. We used a chromosome 17 alpha-satellite DNA probe and a p53 locus-specific DNA probe. We also performed immunohistochemical analysis for p53 protein in the same...

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PMID: 15015584

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