Numerical aberrations of chromosome 17 and the p53 locus in small hepatocellular carcinomas.

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Article

Numerical aberrations of chromosome 17 and the p53 locus in small hepatocellular carcinomas.

Anticancer research - 1 Jan 2000

Yano Hiroshi, Nanashima Atsushi, Hidaka Shigekazu, Haseba Masatoshi, Tanaka Kenji, Yamaguchi Hiroyuki, Nakagoe Tohru, Tagawa Yutaka, Nagayasu Takeshi

Abstract excerpt

To investigate numerical aberrations of chromosome 17 and the p53 locus in early stages of hepatocellular carcinoma (HCC), 12 fresh-frozen specimens of small HCCs (less than 30 mm in size) were examined by dual-color fluorescence in situ hybridization. We used a chromosome 17 alpha-satellite DNA probe and a p53 locus-specific DNA probe. We also performed immunohistochemical analysis for p53 protein in the same...

Topics

Adult
Aged
Carcinoma, Hepatocellular
Chromosome Aberrations
Chromosomes, Human, Pair 7
Female
Genes, p53
Humans
In Situ Hybridization, Fluorescence
Liver Neoplasms
Male
Middle Aged
Mutation
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 15015584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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