Article
Interrelationship between TP53 gene deletion, protein expression and chromosome 17 aneusomy in gastric adenocarcinoma.
BMC gastroenterology - 20 Jul 2009
Khayat André S, Guimarães Adriana C, Calcagno Danielle Q, Seabra Aline D, Lima Eleonidas M, Leal Mariana F, Faria Mário H G, Rabenhorst Silvia H B, Assumpção Paulo P, Demachki Samia, Smith Marília A C, Burbano Rommel R
Abstract excerpt
BACKGROUND: This study evaluates the existence of numerical alterations of chromosome 17 and TP53 gene deletion in gastric adenocarcinoma. The p53 protein expression was also evaluated, as well as, possible associations with clinicopathological characteristics. METHODS: Dual-color fluorescence in situ hybridization and immunostaining were performed in twenty gastric cancer samples of individuals from Northern...
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