Allelic loss and gain, but not genomic instability, as the major somatic mutation in primary hepatocellular carcinoma.

doi:10.1002/gcc.1138

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Article

Allelic loss and gain, but not genomic instability, as the major somatic mutation in primary hepatocellular carcinoma.

Genes, chromosomes & cancer - 1 Jul 2001

Wang G, Zhao Y, Liu X, Wang L, Wu C, Zhang W, Liu W, Zhang P, Cong W, Zhu Y, Zhang L, Chen S, Wan D, Zhao X, Huang W, Gu J

Abstract excerpt

To identify genetic abnormalities in primary hepatocellular carcinoma (HCC), we performed microsatellite analysis (MSA) on 60 Chinese HCC specimens. Utilizing a semi-quantitative MSA and 292 highly polymorphic markers spanning all 22 autosomes, we found that somatic allelic imbalance (AI) occurred frequently in HCC. To evaluate the nature of the AI, comparative genomic hybridization was performed on 20 HCC...

Topics

Adult
Aged
Allelic Imbalance
Carcinoma, Hepatocellular
Chromosomes, Human, Pair 17
Female
Gene Amplification
Humans
Liver Neoplasms
Male
Microsatellite Repeats
Middle Aged
Mutation
Nucleic Acid Hybridization

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PMID: 11391792
DOI: 10.1002/gcc.1138

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