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Article

Toll-like receptor 2 as a major gene for asthma in children of European farmers.

The Journal of allergy and clinical immunology - 1 Mar 2004

Eder Waltraud, Klimecki Walt, Yu Lizhi, von Mutius Erika, Riedler Josef, Braun-Fahrländer Charlotte, Nowak Dennis, Martinez Fernando D

Abstract excerpt

BACKGROUND: The finding that the prevalence of asthma and allergies is less frequent in children raised on animal farms has led to the conjecture that exposure to microbial products modifies immune responses. The toll-like receptors (TLRs) represent an evolutionarily conserved family of innate immunity receptors with microbial molecules as ligands. OBJECTIVES: We reasoned that polymorphisms in genes encoding TLRs...

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Source

Identifiers

PMID: 15007351
DOI: 10.1016/j.jaci.2003.12.374

Genes

TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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