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Article

The interaction between farming/rural environment and TLR2, TLR4, TLR6 and CD14 genetic polymorphisms in relation to early- and late-onset asthma.

Scientific reports - 6 Mar 2017

Lau Melisa Y Z, Dharmage Shyamali C, Burgess John A, Win Aung K, Lowe Adrian J, Lodge Caroline, Perret Jennifer, Hui Jennie, Thomas Paul S, Morrison Stephen, Giles Graham G, Hopper John, Abramson Michael J, Walters E Haydn, Matheson Melanie C

Abstract excerpt

Asthma phenotypes based on age-of-onset may be differently influenced by the interaction between variation in toll-like receptor (TLR)/CD14 genes and environmental microbes. We examined the associations between single-nucleotide polymorphisms (SNP) in the TLR/CD14 genes and asthma, and their interaction with proxies of microbial exposure (childhood farm exposure and childhood rural environment). Ten SNPs in four...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28262750
DOI: 10.1038/srep43681
PMCID: PMC5337969

Genes

TLR6
TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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